› › Structure analysis

Crystal structure of the 52kDa domain of human cardiac troponin in the Ca2+ saturated form

X-ray diffraction
3.3Å resolution
PDB entry 1j1e coloured by chain, front view.
PDB entry 1j1e coloured by chain, side view.
PDB entry 1j1e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cardiac Troponin complex
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 21059.89 Ã…2
Buried surface area: 9164.2 Ã…2
Dissociation area: 2,399.64 Ã…2
Dissociation energy (ΔGdiss): 29.37 kcal/mol
Dissociation entropy (TΔSdiss): 12.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148573
Complex Portal ID: CPX-3280
Assembly 2
Download    3D Visualisation
Assembly Name: Cardiac Troponin complex
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 24365.48 Ã…2
Buried surface area: 8809.04 Ã…2
Dissociation area: 2,502.25 Ã…2
Dissociation energy (ΔGdiss): 27.77 kcal/mol
Dissociation entropy (TΔSdiss): 12.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148573
Complex Portal ID: CPX-3280

Macromolecules

Troponin C, slow skeletal and cardiac muscles
Chains: A, D
Length: 161 amino acids
Theoretical weight: 18.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-161; Coverage: 100%)
Gene names: TNNC, TNNC1
Pfam:
InterPro:
CATH: EF-hand
SCOP: Calmodulin-like
Troponin C, slow skeletal and cardiac muscles in PDB entry 1j1e, assembly 1, front view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 1j1e, assembly 1, side view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 1j1e, assembly 1, top view.
Molecule details ›

Search similar proteins

Troponin T, cardiac muscle
Chains: B, E
Length: 106 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45379 (Residues: 193-298; Coverage: 36%)
Gene name: TNNT2
Pfam: Troponin
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Troponin T
Troponin T, cardiac muscle in PDB entry 1j1e, assembly 1, front view.
Troponin T, cardiac muscle in PDB entry 1j1e, assembly 1, side view.
Troponin T, cardiac muscle in PDB entry 1j1e, assembly 1, top view.
Molecule details ›

Search similar proteins

Troponin I, cardiac muscle
Chains: C, F
Length: 180 amino acids
Theoretical weight: 20.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19429 (Residues: 31-210; Coverage: 86%)
Gene names: TNNC1, TNNI3
Pfam: Troponin
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Troponin I
Troponin I, cardiac muscle in PDB entry 1j1e, assembly 1, front view.
Troponin I, cardiac muscle in PDB entry 1j1e, assembly 1, side view.
Troponin I, cardiac muscle in PDB entry 1j1e, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links