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Crystal structure of the 52kDa domain of human cardiac troponin in the Ca2+ saturated form

Source organism: Homo sapiens
Biochemical function: actin filament binding
Biological process: regulation of muscle contraction
Cellular component: troponin complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00992
Domain description: Troponin
Occurring in:
  1. Troponin T, cardiac muscle
  2. Troponin I, cardiac muscle
The deposited structure of PDB entry 1j1e contains 4 copies of Pfam domain PF00992 (Troponin) in Troponin T, cardiac muscle. Showing 2 copies in chain E.
The deposited structure of PDB entry 1j1e contains 2 copies of Pfam domain PF00992 (Troponin) in Troponin I, cardiac muscle. Showing 1 copy in chain F.

PF13499
Domain description: EF-hand domain pair
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles
The deposited structure of PDB entry 1j1e contains 2 copies of Pfam domain PF13499 (EF-hand domain pair) in Troponin C, slow skeletal and cardiac muscles. Showing 1 copy in chain D.

PF13833
Domain description: EF-hand domain pair
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles
The deposited structure of PDB entry 1j1e contains 2 copies of Pfam domain PF13833 (EF-hand domain pair) in Troponin C, slow skeletal and cardiac muscles. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR002048
Domain description: EF-hand domain
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles
IPR038077
Domain description: Troponin domain superfamily
Occurring in:
  1. Troponin T, cardiac muscle
  2. Troponin I, cardiac muscle
IPR001978
Domain description: Troponin
Occurring in:
  1. Troponin T, cardiac muscle
  2. Troponin I, cardiac muscle
IPR018247
Domain description: EF-Hand 1, calcium-binding site
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles
IPR027707
Domain description: Troponin T
Occurring in:
  1. Troponin T, cardiac muscle
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles

Structure domains

CATH CATH domains
1.20.5.350
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Troponin T, cardiac muscle
  2. Troponin I, cardiac muscle
The deposited structure of PDB entry 1j1e contains 2 copies of CATH domain 1.20.5.350 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Troponin T, cardiac muscle. Showing 1 copy in chain E.
The deposited structure of PDB entry 1j1e contains 2 copies of CATH domain 1.20.5.350 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Troponin I, cardiac muscle. Showing 1 copy in chain F.
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles
The deposited structure of PDB entry 1j1e contains 4 copies of CATH domain 1.10.238.10 (Recoverin; domain 1) in Troponin C, slow skeletal and cardiac muscles. Showing 2 copies in chain D.
SCOP SCOP annotations
90254
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Troponin coil-coiled subunits
Occurring in:
  1. Troponin I, cardiac muscle
The deposited structure of PDB entry 1j1e contains 2 copies of SCOP domain 90254 (Troponin I) in Troponin I, cardiac muscle. Showing 1 copy in chain F.
90251
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Troponin coil-coiled subunits
Occurring in:
  1. Troponin T, cardiac muscle
The deposited structure of PDB entry 1j1e contains 2 copies of SCOP domain 90251 (Troponin T) in Troponin T, cardiac muscle. Showing 1 copy in chain E.
47502
Class: All alpha proteins
Fold: EF Hand-like
Superfamily: EF-hand
Occurring in:
  1. Troponin C, slow skeletal and cardiac muscles
The deposited structure of PDB entry 1j1e contains 2 copies of SCOP domain 47502 (Calmodulin-like) in Troponin C, slow skeletal and cardiac muscles. Showing 1 copy in chain D.

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