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Structure of the mechanically activated ion channel Piezo1

Electron Microscopy
3.8Å resolution
PDB entry 6bpz coloured by chain, front view.
PDB entry 6bpz coloured by chain, side view.
PDB entry 6bpz coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Piezo-type mechanosensitive ion channel component 1
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Multimeric state: homo trimer
Accessible surface area: 145734.25 Ã…2
Buried surface area: 15871.28 Ã…2
Dissociation area: 7,935.64 Ã…2
Dissociation energy (ΔGdiss): 94.78 kcal/mol
Dissociation entropy (TΔSdiss): 35.72 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-122833

Macromolecules

Piezo-type mechanosensitive ion channel component 1
Chains: A, B, C
Length: 1423 amino acids
Theoretical weight: 161.97 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: E2JF22 (Residues: 1137-2547; Coverage: 55%)
Gene names: Fam38a, Piezo1
Pfam:
InterPro:
Piezo-type mechanosensitive ion channel component 1 in PDB entry 6bpz, assembly 1, front view.
Piezo-type mechanosensitive ion channel component 1 in PDB entry 6bpz, assembly 1, side view.
Piezo-type mechanosensitive ion channel component 1 in PDB entry 6bpz, assembly 1, top view.
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