› 6bpz

Electron Microscopy
3.8Å resolution

Structure of the mechanically activated ion channel Piezo1

Released:
DOI:
PDB entry 6bpz coloured by chain, front view.
PDB entry 6bpz coloured by chain, side view.
PDB entry 6bpz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the mechanically activated ion channel Piezo1.
Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB
Nature 554 481-486 (2018)
PMID: 29261642
Related structures: EMD-7128

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122833 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Piezo-type mechanosensitive ion channel component 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1423 amino acids
Theoretical weight: 161.97 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: E2JF22 (Residues: 1137-2547; Coverage: 55%)
Gene names: Fam38a, Piezo1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-7128
Expression system: Homo sapiens

Quick links

Citations

83 review citations

Beech et al. (2019)
82 more

14 mentions without citation

Kefauver et al. (2020)
13 more