› 1kug

X-ray diffraction
1.37Å resolution

Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW

Released:
DOI:
PDB entry 1kug coloured by chain, front view.
PDB entry 1kug coloured by chain, side view.
PDB entry 1kug coloured by chain, top view.
Source organism: Protobothrops mucrosquamatus
Primary publication:
Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues.
Huang KF, Chiou SH, Ko TP, Wang AH
Eur J Biochem 269 3047-56 (2002)
PMID: 12071970

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-129590 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Snake venom metalloproteinase TM-3 Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 23.36 KDa
Source organism: Protobothrops mucrosquamatus
UniProt:
  • Canonical: O57413 (Residues: 190-392; Coverage: 44%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)
ENW Chain: B
Molecule details ›
Chain: B
Length: 3 amino acids
Theoretical weight: 429 Da
Source organism: Protobothrops mucrosquamatus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CD 11 x CD
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL17B2
Spacegroup: P41212
Unit cell:
a: 61.151Å b: 61.151Å c: 131.193Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.202
Expression system: Not provided

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Citations

3 review citations

Damm et al. (2021)
2 more

1 mention without citation

Takeda S. (2016)