ÀÖÌìÌÃÓÎÏ·ÍøÕ¾

Day 1/31 of

Prompt: DREAM

Human melatonin receptor MT2 ()

Melatonin promotes sleep and contributes to our vivid dreams

Day 2/31 of

Prompt: SPIDERS

Spider dragline silk protein Spidroin 1 ()

Some dragline spider silk can be as strong or even stronger than steel.

Day 3/31 of

Prompt: PATH

A path of protein folding

FF domain of pre-mRNA-processing factor 40 folds into its native conformation (PDB entry 1uzc) through a transient intermediate (PDB entry 2kzg) that can be captured by fancy NMR.

Day 4/31 of

Prompt: DODGE

SARS-CoV-2 protein ORF8 (PDB entry 7jtl) dodges the immune system by rapidly evolving and interfering with immune responses.

Day 5/31 of

Prompt: MAP

A molecule of MAP kinase (PDB entry 4qtb) - an important enzyme at the crossroads of many cellular signaling pathways

Day 6/31 of

Prompt: GOLDEN

A part of inner capsid particle + dsRNA of the Golden Shiner Reovirus (PDB entry 8FJK)

Day 7/31 of

Prompt: DRIP

Coagulation Factor VIII (PDB entry 1iqd) prevents excessive bleeding by promoting blood clotting. Its deficiency causes hemophilia.

Day 8/31 of

Prompt: TOAD

Toad liver fatty acid binding protein (PDB entry 1p6p)

Day 9/31 of

Prompt: BOUNCE

TA fragment of Myosin (PDB entry 2n11). Myosins are best known for their role in muscle contraction and trafficking cargo in the cell.

Day 10/31 of

Prompt: FORTUNE

This one is a bit personal.

Synthetic insulin (PDB entry 1lph) that saves my life every day.

As a I’m fortunate to have it as so many diseases remain untreatable.

Day 11/31 of

Prompt: WANDER

Yellow Fluorescent Protein (PDB entry 1yfp) lights up and lets us see how proteins wander through the cell.

Day 12/31 of

Prompt: SPICY

Capsaicin receptor TRPV1 (PDB entry 7LR0). This beautiful tetramer lets us feel the heat of spicy chili peppers and warns us of other potentially dangerous things.

Day 13/31 of

Prompt: RISE

Active site of yeast enzyme pyruvate decarboxylase that breaks pyruvate into acetaldehyde and CO2, which makes the yeast dough rise (PDB entry 1pvd).

Day 14/31 of

Prompt: CASTLE

Tertramerization domain of tumor suppressor protein p53 - “the guardian of the genome� (PDB entry 1sae).

Day 15/31 of

Prompt: DAGGER

a spike of the Type 6 Secretion System (PDB entry 4jiv) does not just look like a dagger, it’s actually used to pierce cells!

Day 16/31 of

Prompt: ANGEL

AZUL domain of ubiquitin ligase UBE3A (PDB entry 8ept)

It’s deficiency causes Angelman syndrome - a genetic disorder that affects nervous system.

Day 17/31 of

Prompt: DEMON

Molecules of Keratin 1 and 10 (PDB entry 6ec0)

Keratins make up hair, nails, horns and hooves in vertebrates

Day 18/31 of

Prompt: SADDLE

TATA-binding protein (PDB entry 1qne)

Doesn’t it look like a saddle? A transcription factor that straddles DNA and interacts with regulatory proteins.

Day 19/31 of

Prompt: PLUMP

Botulinum neurotoxin - the secret ingredient of Botox (PDB entry 2vu9).

It’s used in beauty treatments but also to manage pain and movement disorders.

Day 20/31 of

Prompt: FROST

Bacterial ice-nucleation protein (PDB entry 6m9i) forms a lattice that structures water to induce ice formation

Bacteria in the clouds use it to catch a ride back to Earth.

Day 21/31 of

Prompt: CHAINS

Antibody against Ebola virus (PDB entry 6n7u).

Antibodies consist of light and heavy chains. They block viruses from entering the cell.

Day 22/31 of

Prompt: SCRATCHY

A molecule of major cat allergen Fel d1 (PDB entry 1puo).

Day 23/31 of

Prompt: CELESTIAL

Endonuclease Eco RI (PDB entry 1ckq).

One of the proteins crystallized at the International Space Station.

Day 24/31 of

Prompt: SHALLOW

A pore-forming toxin (PDB entry 4tsy) from strawberry anemone (Actinia fragacea) that thrives in shallow waters.

Day 25/31 of

Prompt: DANGER

Adrenergic receptor beta-2 (PDB entry 6kr8).

It binds to adrenaline and causes our “fight-or-flight� response to danger.

Day 26/31 of

Prompt: REMOVE

De-ubiquitinating enzyme removing a tag.

My favorite is USP7 (PDB entry 1nbf) It’s actually shaped as a right hand.

Day 27/31 of

Prompt: BEAST

Telomerase TERT in action (PDB entry 6usp).

Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA.

Day 28/31 of

Prompt: SPARKLE

Carbonic anhydrase (PDB entry 3uyq).

It contributes to the sparkling feeling we get when drinking carbonated beverages.

Day 29/31 of

Prompt: MASSIVE

Titin - the largest human protein (PDB entry 1tit).

It’s 34,350 residues long and contains 244 domains. It’s key for muscle elasticity.

Day 30/31 of

Prompt: RUSH

Caffeine blocks adenosine A2A receptor (PDB entry 3rfm) and provides a little rush that helps us wake up.

Day 31/31 of

Prompt: FIRE

Inflammasome (PDB entry 3jbl).