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Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex

Electron Microscopy
3.6Å resolution
PDB entry 8enc coloured by chain, front view.
PDB entry 8enc coloured by chain, side view.
PDB entry 8enc coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 129235.46 Ã…2
Buried surface area: 25430.44 Ã…2
Dissociation area: 616.69 Ã…2
Dissociation energy (ΔGdiss): -11.78 kcal/mol
Dissociation entropy (TΔSdiss): 15.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-110397

Macromolecules

Myosin-7
Chain: M
Length: 1935 amino acids
Theoretical weight: 222.93 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P12883 (Residues: 1-1935; Coverage: 100%)
Gene names: MYH7, MYHCB
Pfam:
InterPro:
Myosin-7 in PDB entry 8enc, assembly 1, front view.
Myosin-7 in PDB entry 8enc, assembly 1, side view.
Myosin-7 in PDB entry 8enc, assembly 1, top view.
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Cardiac muscle alpha actin 1
Chains: B, C, D, E, F
Length: 377 amino acids
Theoretical weight: 42.06 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: B6VNT8 (Residues: 1-377; Coverage: 100%)
Gene name: ACTC1
Pfam: Actin
InterPro:
Actin, alpha cardiac muscle 1 in PDB entry 8enc, assembly 1, front view.
Actin, alpha cardiac muscle 1 in PDB entry 8enc, assembly 1, side view.
Actin, alpha cardiac muscle 1 in PDB entry 8enc, assembly 1, top view.
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Tropomyosin alpha-1 chain
Chains: O, P
Length: 284 amino acids
Theoretical weight: 32.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09493 (Residues: 1-284; Coverage: 100%)
Gene names: C15orf13, TMSA, TPM1
Pfam: Tropomyosin
InterPro: Tropomyosin
Tropomyosin alpha-1 chain in PDB entry 8enc, assembly 1, front view.
Tropomyosin alpha-1 chain in PDB entry 8enc, assembly 1, side view.
Tropomyosin alpha-1 chain in PDB entry 8enc, assembly 1, top view.
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