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the Curved Structure of mPIEZO1 in Lipid Bilayer

Electron Microscopy
3.46Å resolution
PDB entry 7wlt coloured by chain, front view.
PDB entry 7wlt coloured by chain, side view.
PDB entry 7wlt coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Piezo-type mechanosensitive ion channel component 1
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Multimeric state: homo trimer
Accessible surface area: 212034.3 Ã…2
Buried surface area: 48031.34 Ã…2
Dissociation area: 11,842.38 Ã…2
Dissociation energy (ΔGdiss): 146.12 kcal/mol
Dissociation entropy (TΔSdiss): 38.03 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-122833

Macromolecules

Piezo-type mechanosensitive ion channel component 1
Chains: A, C, E
Length: 2547 amino acids
Theoretical weight: 292.32 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: E2JF22 (Residues: 1-2547; Coverage: 100%)
Gene names: Fam38a, Piezo1
Pfam:
InterPro:
Piezo-type mechanosensitive ion channel component 1 in PDB entry 7wlt, assembly 1, front view.
Piezo-type mechanosensitive ion channel component 1 in PDB entry 7wlt, assembly 1, side view.
Piezo-type mechanosensitive ion channel component 1 in PDB entry 7wlt, assembly 1, top view.
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