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Serotonin-bound Serotonin 1A (5-HT1A) receptor-Gi protein complex

Electron Microscopy
3Å resolution
PDB entry 7e2y coloured by chain, front view.
PDB entry 7e2y coloured by chain, side view.
PDB entry 7e2y coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 42297.79 Ã…2
Buried surface area: 10776.77 Ã…2
Dissociation area: 1,287.05 Ã…2
Dissociation energy (ΔGdiss): 0.27 kcal/mol
Dissociation entropy (TΔSdiss): 14.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140422

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-1
Chain: A
Length: 354 amino acids
Theoretical weight: 40.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 7e2y, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 7e2y, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 7e2y, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 345 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7e2y, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7e2y, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7e2y, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7e2y, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7e2y, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7e2y, assembly 1, top view.
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5-hydroxytryptamine receptor 1A; Soluble cytochrome b562
Chain: R
Length: 543 amino acids
Theoretical weight: 60.41 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P08908 (Residues: 25-422; Coverage: 94%)
    • nullnull
Gene names: ADRB2RL1, ADRBRL1, HTR1A, cybC
Pfam:
InterPro:
5-hydroxytryptamine receptor 1A in PDB entry 7e2y, assembly 1, front view.
5-hydroxytryptamine receptor 1A in PDB entry 7e2y, assembly 1, side view.
5-hydroxytryptamine receptor 1A in PDB entry 7e2y, assembly 1, top view.
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