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Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Immunoglobulin C1-set
- Immunoglobulin V-set domain
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like fold
- Immunoglobulin-like domain
- Immunoglobulin domain subtype
- Immunoglobulin/major histocompatibility complex, conserved site
- Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
1 more domain
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Amyloid-beta protein 40/42 complex (preferred)
PDBe Complex ID:
PDB-CPX-134616 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin kappa constant
Molecule details ›
Chains: A, D
Length: 219 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Length: 219 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P01834 (Residues: 1-107; Coverage: 100%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin heavy constant gamma 1
Molecule details ›
Chains: B, E
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P01857 (Residues: 1-107; Coverage: 27%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
P3(40)
Molecule details ›
Chains: C, F
Length: 17 amino acids
Theoretical weight: 1.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Beta-amyloid peptide (beta-APP)
Length: 17 amino acids
Theoretical weight: 1.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P05067 (Residues: 683-699; Coverage: 2%)
Sequence domains: Beta-amyloid peptide (beta-APP)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
![Entry percentile scores](/pdbe/entry-files/4xxd_multipercentile_validation.svg")
X-ray source:
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup:
P1
Expression systems:
- Homo sapiens
- Not provided
