› › Function and Biology

Crystal Structure of mid-region amyloid beta capture by solanezumab

Source organism: Homo sapiens
Biochemical function: antigen binding
Biological process: B cell receptor signaling pathway
Cellular component: membrane

Quick links

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
The deposited structure of PDB entry 4xxd contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin kappa constant. Showing 1 copy in chain A.
The deposited structure of PDB entry 4xxd contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin heavy constant gamma 1. Showing 1 copy in chain B.

PF03494
Domain description: Beta-amyloid peptide (beta-APP)
Occurring in:
  1. P3(40)
The deposited structure of PDB entry 4xxd contains 2 copies of Pfam domain PF03494 (Beta-amyloid peptide (beta-APP)) in P3(40). Showing 1 copy in chain C.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
IPR037071
Domain description: Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
Occurring in:
  1. P3(40)
IPR013803
Domain description: Amyloidogenic glycoprotein, amyloid-beta peptide
Occurring in:
  1. P3(40)

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Immunoglobulin kappa constant
  2. Immunoglobulin heavy constant gamma 1
The deposited structure of PDB entry 4xxd contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin kappa constant. Showing 2 copies in chain A.
The deposited structure of PDB entry 4xxd contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin heavy constant gamma 1. Showing 2 copies in chain B.

Quick links