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Crystal Structure of mid-region amyloid beta capture by solanezumab

X-ray diffraction
2.41Å resolution
PDB entry 4xxd coloured by chain, front view.
PDB entry 4xxd coloured by chain, side view.
PDB entry 4xxd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Amyloid-beta protein 40/42 complex
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Multimeric state: hetero trimer
Accessible surface area: 19738.51 Ã…2
Buried surface area: 4677.94 Ã…2
Dissociation area: 875.71 Ã…2
Dissociation energy (ΔGdiss): 10.89 kcal/mol
Dissociation entropy (TΔSdiss): 7.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134616
Assembly 2
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Assembly Name: Amyloid-beta protein 40/42 complex
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Multimeric state: hetero trimer
Accessible surface area: 19682.99 Ã…2
Buried surface area: 4673.5 Ã…2
Dissociation area: 856.2 Ã…2
Dissociation energy (ΔGdiss): 8.59 kcal/mol
Dissociation entropy (TΔSdiss): 7.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134616

Macromolecules

Immunoglobulin kappa constant
Chains: A, D
Length: 219 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin kappa constant in PDB entry 4xxd, assembly 1, front view.
Immunoglobulin kappa constant in PDB entry 4xxd, assembly 1, side view.
Immunoglobulin kappa constant in PDB entry 4xxd, assembly 1, top view.
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Immunoglobulin heavy constant gamma 1
Chains: B, E
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-107; Coverage: 27%)
Gene name: IGHG1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin heavy constant gamma 1 in PDB entry 4xxd, assembly 1, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 4xxd, assembly 1, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 4xxd, assembly 1, top view.
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P3(40)
Chains: C, F
Length: 17 amino acids
Theoretical weight: 1.96 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 683-699; Coverage: 2%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
InterPro:
P3(40) in PDB entry 4xxd, assembly 1, front view.
P3(40) in PDB entry 4xxd, assembly 1, side view.
P3(40) in PDB entry 4xxd, assembly 1, top view.
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