› 4j4m

X-ray diffraction
1.8Å resolution

Crystal structure of TM-1, a Trimeresurus mucrosquamatus venom metalloproteinase

Released:
DOI:
PDB entry 4j4m coloured by chain, front view.
PDB entry 4j4m coloured by chain, side view.
PDB entry 4j4m coloured by chain, top view.
Source organism: Protobothrops mucrosquamatus
Primary publication:
Crystal structure of a Trimeresurus mucrosquamatus venom metalloproteinase providing new insights into the inhibition by endogenous tripeptide inhibitors.
Chou TL, Wu CH, Huang KF, Wang AH
Toxicon 71 140-6 (2013)
PMID: 23732127

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197543 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase TM-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 202 amino acids
Theoretical weight: 21.81 KDa
Source organism: Protobothrops mucrosquamatus
UniProt:
  • Canonical: U3KRG1 (Residues: 1-202; Coverage: 100%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

1 bound ligand:
Ligand ZN 6 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P61
Unit cell:
a: 80.766Å b: 80.766Å c: 120.451Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.184 0.207

Quick links

Citations

3 review citations

Kini et al. (2016)
2 more

3 mentions without citation

Takeda S. (2016)
2 more