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Crystal structure of TM-1, a Trimeresurus mucrosquamatus venom metalloproteinase

Source organism: Protobothrops mucrosquamatus
Biochemical function: metal ion binding
Biological process: proteolysis
Cellular component: extracellular region

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF01421
Domain description: Reprolysin (M12B) family zinc metalloprotease
Occurring in:
  1. Snake venom metalloproteinase TM-1
The deposited structure of PDB entry 4j4m contains 2 copies of Pfam domain PF01421 (Reprolysin (M12B) family zinc metalloprotease ) in Snake venom metalloproteinase TM-1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR034027
Domain description: Reprolysin domain, adamalysin-type
Occurring in:
  1. Snake venom metalloproteinase TM-1
IPR001590
Domain description: Peptidase M12B, ADAM/reprolysin
Occurring in:
  1. Snake venom metalloproteinase TM-1
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Snake venom metalloproteinase TM-1

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Snake venom metalloproteinase TM-1
The deposited structure of PDB entry 4j4m contains 2 copies of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Snake venom metalloproteinase TM-1. Showing 1 copy in chain B.

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