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Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains

X-ray diffraction
2.7Å resolution
PDB entry 4ccz coloured by chain, front view.
PDB entry 4ccz coloured by chain, side view.
PDB entry 4ccz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Methionine synthase
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Multimeric state: monomeric
Accessible surface area: 24117.96 Ã…2
Buried surface area: 894.03 Ã…2
Dissociation area: 447.02 Ã…2
Dissociation energy (ΔGdiss): -7.06 kcal/mol
Dissociation entropy (TΔSdiss): 5.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189250

Macromolecules

Methionine synthase
Chain: A
Length: 644 amino acids
Theoretical weight: 70.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99707 (Residues: 16-657; Coverage: 51%)
Gene name: MTR
Pfam:
InterPro:
CATH:
Methionine synthase in PDB entry 4ccz, assembly 1, front view.
Methionine synthase in PDB entry 4ccz, assembly 1, side view.
Methionine synthase in PDB entry 4ccz, assembly 1, top view.
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