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Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains

Source organism: Homo sapiens
Biochemical function: cobalamin binding
Biological process: pteridine-containing compound metabolic process
Cellular component: not assigned

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EC 2.1.1.13: Methionine synthase

Reaction catalysed:
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine
Systematic name:
5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
Alternative Name(s):
  • 5-methyltetrahydrofolate--homocysteine S-methyltransferase
  • 5-methyltetrahydrofolate--homocysteine transmethylase
  • B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase
  • Cobalamin-dependent methionine synthase
  • MetH
  • Methionine synthase (cobalamin-dependent)
  • Methionine synthetase
  • Methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase
  • N(5)-methyltetrahydrofolate methyltransferase
  • N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase
  • N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase
  • N-methyltetrahydrofolate:L-homocysteine methyltransferase
  • Tetrahydrofolate methyltransferase
  • Tetrahydropteroylglutamate methyltransferase
  • Tetrahydropteroylglutamic methyltransferase
  • Vitamin B12 methyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00809
Domain description: Pterin binding enzyme
Occurring in:
  1. Methionine synthase
The deposited structure of PDB entry 4ccz contains 1 copy of Pfam domain PF00809 (Pterin binding enzyme) in Methionine synthase. Showing 1 copy in chain A.

PF02574
Domain description: Homocysteine S-methyltransferase
Occurring in:
  1. Methionine synthase
The deposited structure of PDB entry 4ccz contains 1 copy of Pfam domain PF02574 (Homocysteine S-methyltransferase) in Methionine synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000489
Domain description: Pterin-binding domain
Occurring in:
  1. Methionine synthase
IPR011005
Domain description: Dihydropteroate synthase-like superfamily
Occurring in:
  1. Methionine synthase
IPR003726
Domain description: Homocysteine-binding domain
Occurring in:
  1. Methionine synthase
IPR036589
Domain description: Homocysteine-binding domain superfamily
Occurring in:
  1. Methionine synthase
IPR011822
Domain description: Cobalamin-dependent methionine synthase
Occurring in:
  1. Methionine synthase

Structure domains

CATH CATH domains
3.20.20.20
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Dihydropteroate synthase-like
Occurring in:
  1. Methionine synthase
The deposited structure of PDB entry 4ccz contains 1 copy of CATH domain 3.20.20.20 (TIM Barrel) in Methionine synthase. Showing 1 copy in chain A.
3.20.20.330
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Homocysteine-binding-like domain
Occurring in:
  1. Methionine synthase
The deposited structure of PDB entry 4ccz contains 1 copy of CATH domain 3.20.20.330 (TIM Barrel) in Methionine synthase. Showing 1 copy in chain A.

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