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Cryo-EM structure of the adhesion GPCR ADGRD1 in complex with miniGs

Electron Microscopy
2.8Å resolution
PDB entry 7wu2 coloured by chain, front view.
PDB entry 7wu2 coloured by chain, side view.
PDB entry 7wu2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 42193.98 Ã…2
Buried surface area: 11314.9 Ã…2
Dissociation area: 1,222.82 Ã…2
Dissociation energy (ΔGdiss): 0.98 kcal/mol
Dissociation entropy (TΔSdiss): 12.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-211343

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 243 amino acids
Theoretical weight: 28.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63092 (Residues: 204-394; Coverage: 46%)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7wu2, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7wu2, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 7wu2, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 351 amino acids
Theoretical weight: 38.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7wu2, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7wu2, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7wu2, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7wu2, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7wu2, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7wu2, assembly 1, top view.
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Nanobody Nb35
Chain: N
Length: 162 amino acids
Theoretical weight: 17.54 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
Nanobody Nb35 in PDB entry 7wu2, assembly 1, front view.
Nanobody Nb35 in PDB entry 7wu2, assembly 1, side view.
Nanobody Nb35 in PDB entry 7wu2, assembly 1, top view.
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Adhesion G-protein coupled receptor D1, C-terminal fragment
Chain: R
Length: 348 amino acids
Theoretical weight: 38.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6QNK2 (Residues: 545-827; Coverage: 33%)
Gene names: ADGRD1, GPR133, PGR25
Pfam: 7 transmembrane receptor (Secretin family)
InterPro:
Adhesion G-protein coupled receptor D1 in PDB entry 7wu2, assembly 1, front view.
Adhesion G-protein coupled receptor D1 in PDB entry 7wu2, assembly 1, side view.
Adhesion G-protein coupled receptor D1 in PDB entry 7wu2, assembly 1, top view.
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