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Human histidine decarboxylase mutant Y334F soaking with histidine

Source organism: Homo sapiens
Biochemical function: pyridoxal phosphate binding
Biological process: carboxylic acid metabolic process
Cellular component: not assigned

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EC 4.1.1.22: Histidine decarboxylase

Reaction catalysed:
L-histidine = histamine + CO(2)
Systematic name:
L-histidine carboxy-lyase (histamine-forming)
Alternative Name(s):
  • L-histidine carboxy-lyase
  • L-histidine decarboxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00282
Domain description: Pyridoxal-dependent decarboxylase conserved domain
Occurring in:
  1. Histidine decarboxylase
The deposited structure of PDB entry 7eiy contains 2 copies of Pfam domain PF00282 (Pyridoxal-dependent decarboxylase conserved domain) in Histidine decarboxylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010977
Domain description: Aromatic-L-amino-acid decarboxylase
Occurring in:
  1. Histidine decarboxylase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Histidine decarboxylase
IPR021115
Domain description: Pyridoxal-phosphate binding site
Occurring in:
  1. Histidine decarboxylase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Histidine decarboxylase
IPR002129
Domain description: Pyridoxal phosphate-dependent decarboxylase
Occurring in:
  1. Histidine decarboxylase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Histidine decarboxylase

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