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Crystal structure of tubulin in complex with D-DM1-SMe

X-ray diffraction
2.597Å resolution
PDB entry 7e4r coloured by chain, front view.
PDB entry 7e4r coloured by chain, side view.
PDB entry 7e4r coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 80581.42 Ã…2
Buried surface area: 22229.26 Ã…2
Dissociation area: 1,236.43 Ã…2
Dissociation energy (ΔGdiss): -7.95 kcal/mol
Dissociation entropy (TΔSdiss): 14.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-237180

Macromolecules

Tubulin alpha-1B chain
Chains: A, C
Length: 440 amino acids
Theoretical weight: 48.97 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P81947 (Residues: 1-440; Coverage: 98%)
Pfam:
InterPro:
Tubulin alpha-1B chain in PDB entry 7e4r, assembly 1, front view.
Tubulin alpha-1B chain in PDB entry 7e4r, assembly 1, side view.
Tubulin alpha-1B chain in PDB entry 7e4r, assembly 1, top view.
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Tubulin beta-2B chain
Chains: B, D
Length: 431 amino acids
Theoretical weight: 48.39 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6B856 (Residues: 1-431; Coverage: 97%)
Gene name: TUBB2B
Pfam:
InterPro:
Tubulin beta-2B chain in PDB entry 7e4r, assembly 1, front view.
Tubulin beta-2B chain in PDB entry 7e4r, assembly 1, side view.
Tubulin beta-2B chain in PDB entry 7e4r, assembly 1, top view.
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Stathmin-4
Chain: E
Length: 138 amino acids
Theoretical weight: 16.28 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63043 (Residues: 50-187; Coverage: 73%)
Gene name: Stmn4
Pfam: Stathmin family
InterPro:
Stathmin-4 in PDB entry 7e4r, assembly 1, front view.
Stathmin-4 in PDB entry 7e4r, assembly 1, side view.
Stathmin-4 in PDB entry 7e4r, assembly 1, top view.
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Tubulin tyrosine ligase
Chain: F
Length: 380 amino acids
Theoretical weight: 43.83 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
InterPro: Tubulin-tyrosine ligase/Tubulin polyglutamylase
TTL ligase in PDB entry 7e4r, assembly 1, front view.
TTL ligase in PDB entry 7e4r, assembly 1, side view.
TTL ligase in PDB entry 7e4r, assembly 1, top view.
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