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Structure of Adenylate kinase from Escherichia coli in complex with two ADP molecules refined at 1.36 A resolution.

Source organism: Escherichia coli K-12
Biochemical function: nucleobase-containing compound kinase activity
Biological process: nucleoside monophosphate phosphorylation
Cellular component: cytosol

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EC 2.7.4.3: Adenylate kinase

Reaction catalysed:
ATP + AMP = 2 ADP
Systematic name:
ATP:AMP phosphotransferase
Alternative Name(s):
  • 5'-AMP-kinase
  • Adenylic kinase
  • Adenylokinase
  • Myokinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05191
Domain description: Adenylate kinase, active site lid
Occurring in:
  1. Adenylate kinase
The deposited structure of PDB entry 7apu contains 2 copies of Pfam domain PF05191 (Adenylate kinase, active site lid) in Adenylate kinase. Showing 1 copy in chain A.

PF00406
Domain description: Adenylate kinase
Occurring in:
  1. Adenylate kinase
The deposited structure of PDB entry 7apu contains 2 copies of Pfam domain PF00406 (Adenylate kinase) in Adenylate kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000850
Domain description: Adenylate kinase/UMP-CMP kinase
Occurring in:
  1. Adenylate kinase
IPR007862
Domain description: Adenylate kinase, active site lid domain
Occurring in:
  1. Adenylate kinase
IPR033690
Domain description: Adenylate kinase, conserved site
Occurring in:
  1. Adenylate kinase
IPR006259
Domain description: Adenylate kinase subfamily
Occurring in:
  1. Adenylate kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Adenylate kinase

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