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Crystal structure of ACPA E4 in complex with CII-C-13-CIT

X-ray diffraction
1.75Å resolution
PDB entry 5ocx coloured by chain, front view.
PDB entry 5ocx coloured by chain, side view.
PDB entry 5ocx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Collagen alpha-1(II) chain and IG-light lambda chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 18953.46 Ã…2
Buried surface area: 5364.66 Ã…2
Dissociation area: 700.91 Ã…2
Dissociation energy (ΔGdiss): -2.87 kcal/mol
Dissociation entropy (TΔSdiss): 7.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208766

Macromolecules

Fab fragment anti-citrullinated protein antibody E4 - light chain
Chain: L
Length: 217 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Fab fragment anti-citrullinated protein antibody E4 - light chain in PDB entry 5ocx, assembly 1, front view.
Fab fragment anti-citrullinated protein antibody E4 - light chain in PDB entry 5ocx, assembly 1, side view.
Fab fragment anti-citrullinated protein antibody E4 - light chain in PDB entry 5ocx, assembly 1, top view.
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Fab fragment of anti-citrullinated protein antibody E4 - heavy chain
Chain: H
Length: 221 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Fab fragment of anti-citrullinated protein antibody E4 - heavy chain in PDB entry 5ocx, assembly 1, front view.
Fab fragment of anti-citrullinated protein antibody E4 - heavy chain in PDB entry 5ocx, assembly 1, side view.
Fab fragment of anti-citrullinated protein antibody E4 - heavy chain in PDB entry 5ocx, assembly 1, top view.
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Collagen alpha-1(II) chain
Chain: A
Length: 18 amino acids
Theoretical weight: 1.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02458 (Residues: 484-498; Coverage: 1%)
Gene name: COL2A1
Collagen alpha-1(II) chain in PDB entry 5ocx, assembly 1, front view.
Collagen alpha-1(II) chain in PDB entry 5ocx, assembly 1, side view.
Collagen alpha-1(II) chain in PDB entry 5ocx, assembly 1, top view.
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