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The X-ray crystal structure of lymphocyte perforin

Source organism: Mus musculus
Biochemical function: pore-forming activity
Biological process: granzyme-mediated programmed cell death signaling pathway
Cellular component: cytolytic granule

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00168
Domain description: C2 domain
Occurring in:
  1. Perforin-1
The deposited structure of PDB entry 3nsj contains 1 copy of Pfam domain PF00168 (C2 domain) in Perforin-1. Showing 1 copy in chain A.

PF01823
Domain description: MAC/Perforin domain
Occurring in:
  1. Perforin-1
The deposited structure of PDB entry 3nsj contains 1 copy of Pfam domain PF01823 (MAC/Perforin domain) in Perforin-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000008
Domain description: C2 domain
Occurring in:
  1. Perforin-1
IPR020864
Domain description: Membrane attack complex component/perforin (MACPF) domain
Occurring in:
  1. Perforin-1
IPR035892
Domain description: C2 domain superfamily
Occurring in:
  1. Perforin-1
IPR037300
Domain description: Perforin-1, C2 domain
Occurring in:
  1. Perforin-1
IPR020863
Domain description: Membrane attack complex component/perforin domain, conserved site
Occurring in:
  1. Perforin-1

Structure domain

CATH CATH domain
2.60.40.150
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: C2 domain
Occurring in:
  1. Perforin-1
The deposited structure of PDB entry 3nsj contains 1 copy of CATH domain 2.60.40.150 (Immunoglobulin-like) in Perforin-1. Showing 1 copy in chain A.

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