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Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine

X-ray diffraction
1.7Å resolution
PDB entry 2q72 coloured by chain, front view.
PDB entry 2q72 coloured by chain, side view.
PDB entry 2q72 coloured by chain, top view.
Source organism: Aquifex aeolicus VF5
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Na(+):neurotransmitter symporter (Snf family)
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Multimeric state: monomeric
Accessible surface area: 20399.77 Ã…2
Buried surface area: 3252.66 Ã…2
Dissociation area: 0 Ã…2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130575
Assembly 2
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Assembly Name: Na(+):neurotransmitter symporter (Snf family)
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Multimeric state: homo dimer
Accessible surface area: 36626.69 Ã…2
Buried surface area: 10684.05 Ã…2
Dissociation area: 2,110.57 Ã…2
Dissociation energy (ΔGdiss): -3.83 kcal/mol
Dissociation entropy (TΔSdiss): 14.86 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-130578

Macromolecules

Na(+):neurotransmitter symporter (Snf family)
Chain: A
Length: 519 amino acids
Theoretical weight: 58.08 KDa
Source organism: Aquifex aeolicus VF5
Expression system: Escherichia coli
UniProt:
  • Canonical: O67854 (Residues: 1-513; Coverage: 100%)
Gene names: aq_2077, snf
Pfam: Sodium:neurotransmitter symporter family
InterPro:
SCOP: SNF-like
Na(+):neurotransmitter symporter (Snf family) in PDB entry 2q72, assembly 1, front view.
Na(+):neurotransmitter symporter (Snf family) in PDB entry 2q72, assembly 1, side view.
Na(+):neurotransmitter symporter (Snf family) in PDB entry 2q72, assembly 1, top view.
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