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Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation

Solid-state NMR
PDB entry 2mvx coloured by chain, ensemble of 20 models, front view.
PDB entry 2mvx coloured by chain, ensemble of 20 models, side view.
PDB entry 2mvx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
homo decamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble APP-beta
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Multimeric state: homo decamer
Accessible surface area: 12776.38 Ã…2
Buried surface area: 31526.14 Ã…2
Dissociation area: 3,966.99 Ã…2
Dissociation energy (ΔGdiss): 39.26 kcal/mol
Dissociation entropy (TΔSdiss): 13.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138391

Macromolecules

Amyloid-beta protein 40
Chains: A, B, C, D, E, F, G, H, I, J
Length: 39 amino acids
Theoretical weight: 4.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
InterPro:
Amyloid-beta protein 40 in PDB entry 2mvx, assembly 1, front view.
Amyloid-beta protein 40 in PDB entry 2mvx, assembly 1, side view.
Amyloid-beta protein 40 in PDB entry 2mvx, assembly 1, top view.
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