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CRYSTAL STRUCTURE OF ARCHAEAL PREFOLDIN (GIMC).

X-ray diffraction
2.3Å resolution
PDB entry 1fxk coloured by chain, front view.
PDB entry 1fxk coloured by chain, side view.
PDB entry 1fxk coloured by chain, top view.
Source organism: Methanothermobacter thermautotrophicus
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Prefoldin subunit alpha and Prefoldin subunit beta
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Multimeric state: hetero hexamer
Accessible surface area: 42841.91 Ã…2
Buried surface area: 9492.47 Ã…2
Dissociation area: 2,179.64 Ã…2
Dissociation energy (ΔGdiss): 8.87 kcal/mol
Dissociation entropy (TΔSdiss): 25.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127853

Macromolecules

Prefoldin subunit beta
Chain: A
Length: 107 amino acids
Theoretical weight: 12.73 KDa
Source organism: Methanothermobacter thermautotrophicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O26774 (Residues: 5-111; Coverage: 88%)
Gene names: MTH_678, pfdB
Pfam: Prefoldin subunit
InterPro:
CATH: Helix Hairpins
SCOP: Prefoldin
Prefoldin subunit beta in PDB entry 1fxk, assembly 1, front view.
Prefoldin subunit beta in PDB entry 1fxk, assembly 1, side view.
Prefoldin subunit beta in PDB entry 1fxk, assembly 1, top view.
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Prefoldin subunit beta
Chain: B
Length: 109 amino acids
Theoretical weight: 12.78 KDa
Source organism: Methanothermobacter thermautotrophicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O26774 (Residues: 6-114; Coverage: 90%)
Gene names: MTH_678, pfdB
Pfam: Prefoldin subunit
InterPro:
CATH: Helix Hairpins
SCOP: Prefoldin
Prefoldin subunit beta in PDB entry 1fxk, assembly 1, front view.
Prefoldin subunit beta in PDB entry 1fxk, assembly 1, side view.
Prefoldin subunit beta in PDB entry 1fxk, assembly 1, top view.
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Prefoldin subunit alpha
Chain: C
Length: 133 amino acids
Theoretical weight: 14.38 KDa
Source organism: Methanothermobacter thermautotrophicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O27646 (Residues: 7-136; Coverage: 92%)
Gene names: MTH_1609, pfdA
Pfam: Prefoldin subunit
InterPro:
CATH: Helix Hairpins
SCOP: Prefoldin
Prefoldin subunit alpha in PDB entry 1fxk, assembly 1, front view.
Prefoldin subunit alpha in PDB entry 1fxk, assembly 1, side view.
Prefoldin subunit alpha in PDB entry 1fxk, assembly 1, top view.
Molecule details ›

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