› 7wlu

Electron Microscopy
6.81Å resolution

The Flattened Structure of mPIEZO1 in Lipid Bilayer

Released:
DOI:
PDB entry 7wlu coloured by chain, front view.
PDB entry 7wlu coloured by chain, side view.
PDB entry 7wlu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure deformation and curvature sensing of PIEZO1 in lipid membranes.
Yang X, Lin C, Chen X, Li S, Li X, Xiao B
Nature 604 377-383 (2022)
PMID: 35388220
Related structures: EMD-32593

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122833 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Piezo-type mechanosensitive ion channel component 1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 2547 amino acids
Theoretical weight: 292.32 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: E2JF22 (Residues: 1-2547; Coverage: 100%)
Gene names: Fam38a, Piezo1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PLX 3 x PLX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.81Å
Relevant EMDB volumes: EMD-32593
Expression system: Homo sapiens

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Citations

22 review citations

Davis et al. (2023)
21 more

1 mention without citation

Peralta et al. (2023)