› 7pag

Electron Microscopy
4Å resolution

The pore conformation of lymphocyte perforin

Released:
DOI:
PDB entry 7pag coloured by chain, front view.
PDB entry 7pag coloured by chain, side view.
PDB entry 7pag coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The pore conformation of lymphocyte perforin.
Ivanova ME, Lukoyanova N, Malhotra S, Topf M, Trapani JA, Voskoboinik I, Saibil HR
OpenAccess logo Sci Adv 8 eabk3147 (2022)
PMID: 35148176
Related structures: EMD-13269

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Perforin-1 Chain: A
Molecule details ›
Chain: A
Length: 540 amino acids
Theoretical weight: 60.83 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10820 (Residues: 21-554; Coverage: 100%)
Gene names: Pfp, Prf1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-13269
Expression system: Spodoptera frugiperda

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Citations

3 review citations

Margheritis et al. (2023)
2 more

3 mentions without citation

Stadermann et al. (2024)
2 more