5mu2 › Citations

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

Ge C, Tong D, Liang B, L枚nnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R
JCI Insight 2 (2017)
Related entries: 5mu0, 5mub, 5mv3, 5mv4

Cited: 32 times
EuropePMC logo PMID:
doi logo

Abstract

Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of collagen type II (CII) and its citrullinated variants. We found that these antibodies are commonly occurring in RA. A mAb (ACC1) against citrullinated C1 was found to cross-react with several noncitrullinated epitopes on native CII, causing proteoglycan depletion of cartilage and severe arthritis in mice. Structural studies by X-ray crystallography showed that such recognition is governed by a shared structural motif "RG-TG" within all the epitopes, including electrostatic potential-controlled citrulline specificity. Overall, we have demonstrated a molecular mechanism that explains how ACPAs trigger arthritis.

Articles - 5mu2 mentioned but not cited (1)

  1. Ge C, Tong D, Liang B, L枚nnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R. JCI Insight 2 93688 (2017)


Reviews citing this publication (15)

  1. Holers VM, Banda NK. Front Immunol 9 1057 (2018)
  2. Sprouse ML, Bates NA, Felix KM, Wu HJ. Immunology 156 305-318 (2019)
  3. Mueller AL, Payandeh Z, Mohammadkhani N, Mubarak SMH, Zakeri A, Alagheband Bahrami A, Brockmueller A, Shakibaei M. Cells 10 3017 (2021)
  4. Wu CY, Yang HY, Lai JH. Int J Mol Sci 21 E4015 (2020)
  5. Chang MH, Nigrovic PA. JCI Insight 4 125278 (2019)
  6. Zhou X, Motta F, Selmi C, Ridgway WM, Gershwin ME, Zhang W. Autoimmun Rev 20 102804 (2021)
  7. Vletter EM, Koning MT, Scherer HU, Veelken H, Toes REM. Front Immunol 11 241 (2020)
  8. Yu HC, Lu MC. Tzu Chi Med J 31 5-10 (2019)
  9. Tsai CY, Hsieh SC, Liu CW, Lu CH, Liao HT, Chen MH, Li KJ, Wu CH, Shen CY, Kuo YM, Yu CL. Int J Mol Sci 22 5689 (2021)
  10. Rantap盲盲 Dahlqvist S, Andrade F. J Intern Med 286 627-643 (2019)
  11. Liu J, Gao J, Wu Z, Mi L, Li N, Wang Y, Peng X, Xu K, Wu F, Zhang L. Front Med (Lausanne) 8 802934 (2021)
  12. Rom茫o VC, Fonseca JE. Front Med (Lausanne) 9 689711 (2022)
  13. Trier NH, Houen G. Int J Mol Sci 24 13609 (2023)
  14. Batsalova T, Dzhambazov B. Int J Mol Sci 24 9884 (2023)
  15. H盲upl T, Skapenko A, Hoppe B, Skriner K, Burkhardt H, Poddubnyy D, Ohrndorf S, Sewerin P, Mansmann U, Stuhlm眉ller B, Schulze-Koops H, Burmester GR. Z Rheumatol 77 16-23 (2018)

Articles citing this publication (16)

  1. Ge C, Xu B, Liang B, L枚nnblom E, Lundstr枚m SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmstr枚m V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R. Arthritis Rheumatol 71 210-221 (2019)
  2. Dahdah A, Habir K, Nandakumar KS, Saxena A, Xu B, Holmdahl R, Malin S. Arthritis Rheumatol 70 193-203 (2018)
  3. Li Y, Tong D, Liang P, L枚nnblom E, Viljanen J, Xu B, Nandakumar KS, Holmdahl R. Arthritis Res Ther 22 120 (2020)
  4. Cao Y, Song Z, Guo Z, Zhao X, Gong Y, Zhao K, Qu C, Huang Y, Li Y, Gao Y, Zhang J, Guo X. Front Immunol 12 724379 (2021)
  5. Kang J, Jeong SH, Lee K, Park N, Jung H, Lee K, Ju JH. PLoS One 15 e0230719 (2020)
  6. Tong D, L枚nnblom E, Yau ACY, Nandakumar KS, Liang B, Ge C, Viljanen J, Li L, B茫lan M, Klareskog L, Chagin AS, Gjertsson I, Kihlberg J, Zhao M, Holmdahl R. Front Immunol 9 451 (2018)
  7. Joo YB, Park YJ, Park KS, Kim KJ. Clin Rheumatol 38 2423-2432 (2019)
  8. Yamada H, Ozawa T, Kishi H, Okada S, Nakashima Y, Muraguchi A, Yoshikai Y. J Immunol 201 3492-3496 (2018)
  9. He Y, Ge C, Moreno-Gir贸 脌, Xu B, Beusch CM, Sandor K, Su J, Cheng L, L枚nnblom E, Lundqvist C, Slot LM, Tong D, Urbonaviciute V, Liang B, Li T, Lahore GF, Aoun M, Malmstr枚m V, Rispens T, Ernfors P, Svensson CI, Scherer HU, Toes REM, Gjertsson I, Ekwall O, Zubarev RA, Holmdahl R. Nat Commun 14 691 (2023)
  10. Zhao Y, Urbonaviciute V, Xu B, Cai W, Sener Z, Ge C, Holmdahl R. Front Immunol 12 631249 (2021)
  11. Li Q, Li Y, Liang B, Xu R, Xu B, L枚nnblom E, Feng H, Bai J, Stawikowska R, Ge C, Lu A, Fields GB, Xiao L, Holmdahl R. Arthritis Res Ther 24 257 (2022)
  12. Xu Z, Xu B, Lundstr枚m SL, Moreno-Gir贸 脌, Zhao D, Martin M, L枚nnblom E, Li Q, Kr盲mer A, Ge C, Cheng L, Liang B, Tong D, Stawikowska R, Blom AM, Fields GB, Zubarev RA, Holmdahl R. Nat Commun 14 5949 (2023)
  13. Xu Z, Walker S, Wise MC, Chokkalingam N, Purwar M, Moore A, Tello-Ruiz E, Wu Y, Majumdar S, Konrath KM, Kulkarni A, Tursi NJ, Zaidi FI, Reuschel EL, Patel I, Obeirne A, Du J, Schultheis K, Gites L, Smith T, Mendoza J, Broderick KE, Humeau L, Pallesen J, Weiner DB, Kulp DW. Nat Commun 13 695 (2022)
  14. Myers LK, Ouyang YX, Patel JR, Odens HH, Woo-Rasberry V, Park J, Yi AK, Rosloniec EF, Brand DD, Stuart JM, Kang AH. Int J Mol Sci 23 9833 (2022)
  15. Batsalova T, Teneva I, Bardarov K, Moten D, Dzhambazov B. Cent Eur J Immunol 48 174-188 (2023)
  16. Liang P, Li Y, Xu R, Nandakumar KS, Stawikowska R, Fields GB, Holmdahl R. Mol Biomed 3 14 (2022)


Quick links