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Anaerobic crystal structure of delta413-417:GS LOX in complex with arachidonate

Source organism: Plexaura homomalla
Biochemical function: metal ion binding
Biological process: lipid oxidation
Cellular component: not assigned

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EC 1.13.11.40: Arachidonate 8-lipoxygenase

Reaction catalysed:
Arachidonate + O(2) = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
Systematic name:
Arachidonate:oxygen 8-oxidoreductase
Alternative Name(s):
  • 8(R)-lipoxygenase
  • 8-lipoxygenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00305
Domain description: Lipoxygenase
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
The deposited structure of PDB entry 4qwt contains 4 copies of Pfam domain PF00305 (Lipoxygenase) in Allene oxide synthase-lipoxygenase protein. Showing 1 copy in chain C.

PF01477
Domain description: PLAT/LH2 domain
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
The deposited structure of PDB entry 4qwt contains 4 copies of Pfam domain PF01477 (PLAT/LH2 domain) in Allene oxide synthase-lipoxygenase protein. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR013819
Domain description: Lipoxygenase, C-terminal
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR001885
Domain description: Lipoxygenase, mammalian
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR001024
Domain description: PLAT/LH2 domain
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR020834
Domain description: Lipoxygenase, conserved site
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR020833
Domain description: Lipoxygenase, iron binding site
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR036226
Domain description: Lipoxigenase, C-terminal domain superfamily
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR000907
Domain description: Lipoxygenase
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
IPR036392
Domain description: PLAT/LH2 domain superfamily
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein

Structure domains

CATH CATH domains
1.20.245.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Lipoxygenase-1; domain 5
Homology: Lipoxygenase-1; Domain 5
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
The deposited structure of PDB entry 4qwt contains 4 copies of CATH domain 1.20.245.10 (Lipoxygenase-1; domain 5) in Allene oxide synthase-lipoxygenase protein. Showing 1 copy in chain C.
3.10.450.60
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
The deposited structure of PDB entry 4qwt contains 4 copies of CATH domain 3.10.450.60 (Nuclear Transport Factor 2; Chain: A,) in Allene oxide synthase-lipoxygenase protein. Showing 1 copy in chain C.
2.60.60.20
Class: Mainly Beta
Architecture: Sandwich
Topology: Lipoxygenase-1
Homology: PLAT/LH2 domain
Occurring in:
  1. Allene oxide synthase-lipoxygenase protein
The deposited structure of PDB entry 4qwt contains 4 copies of CATH domain 2.60.60.20 (Lipoxygenase-1) in Allene oxide synthase-lipoxygenase protein. Showing 1 copy in chain C.

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