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An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.

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Cao M, Liu X, Zhang Y, Xue X, Zhou XE, Melcher K, Gao P, Wang F, Zeng L, Zhao Y, Zhao Y, Deng P, Zhong D, Zhu JK, Xu HE, Xu Y
OpenAccess logo Cell Res 23 1043-54 (2013)
Related entries: 4lg5, 4lgb

Cited: 74 times
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Abstract

Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly to the PYR/PYL family of ABA receptors, resulting in inhibition of type 2C phosphatases (PP2C) and activation of downstream ABA signaling. It is envisioned that intervention of ABA signaling by small molecules could help plants to overcome abiotic stresses such as drought, cold and soil salinity. However, chemical instability and rapid catabolism by plant enzymes limit the practical application of ABA itself. Here we report the identification of a small molecule ABA mimic (AM1) that acts as a potent activator of multiple members of the family of ABA receptors. In Arabidopsis, AM1 activates a gene network that is highly similar to that induced by ABA. Treatments with AM1 inhibit seed germination, prevent leaf water loss, and promote drought resistance. We solved the crystal structure of AM1 in complex with the PYL2 ABA receptor and the HAB1 PP2C, which revealed that AM1 mediates a gate-latch-lock interacting network, a structural feature that is conserved in the ABA-bound receptor/PP2C complex. Together, these results demonstrate that a single small molecule ABA mimic can activate multiple ABA receptors and protect plants from water loss and drought stress. Moreover, the AM1 complex crystal structure provides a structural basis for designing the next generation of ABA-mimicking small molecules.

Reviews - 4lga mentioned but not cited (1)

  1. Hewage KAH, Yang JF, Wang D, Hao GF, Yang GF, Zhu JK. Adv Sci (Weinh) 7 2001265 (2020)

Articles - 4lga mentioned but not cited (1)

  1. Cao M, Liu X, Zhang Y, Xue X, Zhou XE, Melcher K, Gao P, Wang F, Zeng L, Zhao Y, Zhao Y, Deng P, Zhong D, Zhu JK, Xu HE, Xu Y. Cell Res 23 1043-1054 (2013)


Reviews citing this publication (18)

  1. Mickelbart MV, Hasegawa PM, Bailey-Serres J. Nat Rev Genet 16 237-251 (2015)
  2. Zhang H, Zhu J, Gong Z, Zhu JK. Nat Rev Genet 23 104-119 (2022)
  3. Munemasa S, Hauser F, Park J, Waadt R, Brandt B, Schroeder JI. Curr Opin Plant Biol 28 154-162 (2015)
  4. Shanker AK, Maheswari M, Yadav SK, Desai S, Bhanu D, Attal NB, Venkateswarlu B. Funct Integr Genomics 14 11-22 (2014)
  5. Ng LM, Melcher K, Teh BT, Xu HE. Acta Pharmacol Sin 35 567-584 (2014)
  6. Chen R, Deng Y, Ding Y, Guo J, Qiu J, Wang B, Wang C, Xie Y, Zhang Z, Chen J, Chen L, Chu C, He G, He Z, Huang X, Xing Y, Yang S, Xie D, Liu Y, Li J. Sci China Life Sci 65 33-92 (2022)
  7. Zhang XL, Jiang L, Xin Q, Liu Y, Tan JX, Chen ZZ. Front Plant Sci 6 88 (2015)
  8. Verslues PE. Plant Mol Biol 91 629-640 (2016)
  9. Rigal A, Ma Q, Robert S. Front Plant Sci 5 373 (2014)
  10. Jiang K, Asami T. Biosci Biotechnol Biochem 82 1265-1300 (2018)
  11. Fonseca S, Rosado A, Vaughan-Hirsch J, Bishopp A, Chini A. Front Plant Sci 5 709 (2014)
  12. Fanourakis D, Bouranis D, Giday H, Carvalho DR, Rezaei Nejad A, Ottosen CO. J Plant Physiol 207 51-60 (2016)
  13. Zhang H, Sun X, Dai M. Plant Commun 3 100228 (2022)
  14. Maggio A, Bressan RA, Zhao Y, Park J, Yun DJ. Int J Mol Sci 19 E3671 (2018)
  15. Hu S, Lübberstedt T. Trends Plant Sci 20 372-379 (2015)
  16. Lumba S, Bunsick M, McCourt P. F1000Res 6 975 (2017)
  17. Liu Y, Chen S, Wei P, Guo S, Wu J. Front Chem 10 967404 (2022)
  18. Lepri A, Longo C, Messore A, Kazmi H, Madia VN, Di Santo R, Costi R, Vittorioso P. Plants (Basel) 12 1729 (2023)

Articles citing this publication (54)

  1. Zhao Y, Chan Z, Gao J, Xing L, Cao M, Yu C, Hu Y, You J, Shi H, Zhu Y, Gong Y, Mu Z, Wang H, Deng X, Wang P, Bressan RA, Zhu JK. Proc Natl Acad Sci U S A 113 1949-1954 (2016)
  2. Park SY, Peterson FC, Mosquna A, Yao J, Volkman BF, Cutler SR. Nature 520 545-548 (2015)
  3. González-Guzmán M, Rodríguez L, Lorenzo-Orts L, Pons C, Sarrión-Perdigones A, Fernández MA, Peirats-Llobet M, Forment J, Moreno-Alvero M, Cutler SR, Albert A, Granell A, Rodríguez PL. J Exp Bot 65 4451-4464 (2014)
  4. Hachez C, Veljanovski V, Reinhardt H, Guillaumot D, Vanhee C, Chaumont F, Batoko H. Plant Cell 26 4974-4990 (2014)
  5. Toh S, Holbrook-Smith D, Stokes ME, Tsuchiya Y, McCourt P. Chem Biol 21 988-998 (2014)
  6. Rodriguez L, Gonzalez-Guzman M, Diaz M, Rodrigues A, Izquierdo-Garcia AC, Peirats-Llobet M, Fernandez MA, Antoni R, Fernandez D, Marquez JA, Mulet JM, Albert A, Albert A, Rodriguez PL. Plant Cell 26 4802-4820 (2014)
  7. Fuchs S, Tischer SV, Wunschel C, Christmann A, Grill E. Proc Natl Acad Sci U S A 111 5741-5746 (2014)
  8. Wang Y, Cordewener JH, America AH, Shan W, Bouwmeester K, Govers F. Mol Plant Microbe Interact 28 1032-1048 (2015)
  9. Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J, Wu WW, Wang FX, Xu HE, Zhu JK. Nat Commun 8 1183 (2017)
  10. Fan SK, Fang XZ, Guan MY, Ye YQ, Lin XY, Du ST, Jin CW. Front Plant Sci 5 721 (2014)
  11. Zhou L, Xu H, Mischke S, Meinhardt LW, Zhang D, Zhu X, Li X, Fang W. Hortic Res 1 14029 (2014)
  12. Belda-Palazon B, Gonzalez-Garcia MP, Lozano-Juste J, Coego A, Antoni R, Julian J, Peirats-Llobet M, Rodriguez L, Berbel A, Dietrich D, Fernandez MA, Madueño F, Bennett MJ, Rodriguez PL. Proc Natl Acad Sci U S A 115 E11857-E11863 (2018)
  13. Ye Y, Zhou L, Liu X, Liu H, Li D, Cao M, Chen H, Xu L, Zhu JK, Zhao Y. Plant Physiol 173 2356-2369 (2017)
  14. Zhang Y, Xue X, Jin X, Song Y, Li J, Luo X, Song M, Yan W, Song H, Xu Y. Eur J Med Chem 78 431-441 (2014)
  15. Fan Q, Song A, Jiang J, Zhang T, Sun H, Wang Y, Chen S, Chen F. PLoS One 11 e0150572 (2016)
  16. Ye Y, Gong Z, Lu X, Miao D, Shi J, Lu J, Zhao Y. Plant J 85 3-15 (2016)
  17. Hong Y, Wang Z, Liu X, Yao J, Kong X, Shi H, Zhu JK. Plant Physiol 182 1007-1021 (2020)
  18. Duarte KE, de Souza WR, Santiago TR, Santiago TR, Sampaio BL, Ribeiro AP, Cotta MG, da Cunha BADB, Marraccini PRR, Kobayashi AK, Molinari HBC. Sci Rep 9 4028 (2019)
  19. Li H, Li M, Wei X, Zhang X, Xue R, Zhao Y, Zhao H. Mol Genet Genomics 292 1091-1110 (2017)
  20. Benson CL, Kepka M, Wunschel C, Rajagopalan N, Nelson KM, Christmann A, Abrams SR, Grill E, Loewen MC. Phytochemistry 113 96-107 (2015)
  21. Feng G, Wu J, Xu Y, Lu L, Yi H. Plant Biotechnol J 19 1337-1353 (2021)
  22. Li H, Yang Y, Wang H, Liu S, Jia F, Su Y, Li S, He F, Feng C, Niu M, Wang J, Liu C, Yin W, Xia X. Int J Mol Sci 22 7245 (2021)
  23. Nemoto K, Kagawa M, Nozawa A, Hasegawa Y, Hayashi M, Imai K, Tomii K, Sawasaki T. Sci Rep 8 4268 (2018)
  24. Schott-Verdugo S, Müller L, Classen E, Gohlke H, Groth G. Sci Rep 9 8869 (2019)
  25. Molinari MDC, Fuganti-Pagliarini R, Marin SRR, Ferreira LC, Barbosa DA, Marcolino-Gomes J, Oliveira MCN, Mertz-Henning LM, Kanamori N, Takasaki H, Urano K, Shinozaki K, Nakashima K, Yamaguchi-Shinozaki K, Nepomuceno AL. Genet Mol Biol 43 e20190292 (2020)
  26. Yuan J, Meng J, Liang X, E Y, Yang X, Chen W. Front Plant Sci 8 1624 (2017)
  27. Zhou Y, He R, Guo Y, Liu K, Huang G, Peng C, Liu Y, Zhang M, Li Z, Duan L. Sci Rep 9 2887 (2019)
  28. Song C, Yan Y, Rosado A, Zhang Z, Castellarin SD. Front Plant Sci 10 872 (2019)
  29. Song Y, Xue X, Wu X, Wang R, Xing Y, Yan W, Zhou Y, Qian CN, Zhang Y, Xu Y. Eur J Med Chem 116 13-26 (2016)
  30. Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H. Chembiochem 16 2471-2478 (2015)
  31. Takeuchi J, Ohnishi T, Okamoto M, Todoroki Y. Bioorg Med Chem Lett 25 3507-3510 (2015)
  32. Ren Z, Wang Z, Zhou XE, Shi H, Hong Y, Cao M, Chan Z, Liu X, Xu HE, Zhu JK. Sci Rep 7 14022 (2017)
  33. Feng X, Jia L, Cai Y, Guan H, Zheng D, Zhang W, Xiong H, Zhou H, Wen Y, Hu Y, Zhang X, Wang Q, Wu F, Xu J, Lu Y. Plant Biotechnol J 20 2077-2088 (2022)
  34. Li Y, Wang D, Sun C, Hu X, Mu X, Hu J, Yang Y, Zhang Y, Xie CG, Zhou X. Biochem Biophys Res Commun 487 684-689 (2017)
  35. Rodriguez PL, Lozano-Juste J. Trends Plant Sci 20 330-332 (2015)
  36. Min MK, Kim R, Moon SJ, Lee Y, Han S, Lee S, Kim BG. Sci Rep 10 4 (2020)
  37. Han S, Lee Y, Park EJ, Min MK, Lee Y, Kim TH, Kim BG, Lee S. Plant Mol Biol 100 319-333 (2019)
  38. Geng S, Ren Z, Liang L, Zhang Y, Li Z, Zhou Y, Duan L. Int J Mol Sci 22 12986 (2021)
  39. Shang Y, Yang D, Ha Y, Hur YS, Lee MM, Nam KH. Front Plant Sci 13 849467 (2022)
  40. Hitomi K, Getzoff ED, Schroeder JI. Plant Physiol 163 1087-1088 (2013)
  41. Li W, Li H, Xu P, Xie Z, Ye Y, Li L, Li D, Zhang Y, Li L, Zhao Y. Plant Mol Biol 98 275-287 (2018)
  42. Yang JF, Yin CY, Wang D, Jia CY, Hao GF, Yang GF. Front Chem 8 425 (2020)
  43. Lozano-Juste J, Infantes L, Garcia-Maquilon I, Ruiz-Partida R, Merilo E, Benavente JL, Velazquez-Campoy A, Coego A, Bono M, Forment J, Pampín B, Destito P, Monteiro A, Rodríguez R, Cruces J, Rodriguez PL, Albert A. Sci Adv 9 eade9948 (2023)
  44. Ye Y, Zhao Y. Plant Signal Behav 11 e1144000 (2016)
  45. Yuan J, Meng J, Liang X, Yang E, Yang X, Chen WF. Front Plant Sci 12 646910 (2021)
  46. Yang Z, Xu J, Du L, Yin J, Wang Z, Yi F, Duan L, Li Z, Wang B, Shu K, Tan W. Front Plant Sci 13 902902 (2022)
  47. Zhou S, He L, Lin W, Su Y, Liu Q, Qu M, Xiao L. BMC Genomics 23 862 (2022)
  48. Sun S, Fan W, Mu Z. Plant Signal Behav 12 e1214793 (2017)
  49. Liu R, Liang G, Gong J, Wang J, Zhang Y, Hao Z, Li G. Int J Mol Sci 24 8783 (2023)
  50. Roeder J, Liu J, Doch I, Ruschhaupt M, Christmann A, Grill E, Helmke H, Hohmann S, Lehr S, Frackenpohl J, Yang Z. Front Plant Sci 13 1071710 (2022)
  51. Han Y, Haouel A, Georgii E, Priego-Cubero S, Wurm CJ, Hemmler D, Schmitt-Kopplin P, Becker C, Durner J, Lindermayr C. Genes (Basel) 14 1199 (2023)
  52. Infantes L, Rivera-Moreno M, Daniel-Mozo M, Benavente JL, Ocaña-Cuesta J, Coego A, Lozano-Juste J, Rodriguez PL, Albert A. Front Plant Sci 13 884029 (2022)
  53. Wan C, Li J, Zhao F, Yang D, Che C, Ding S, Hu Y, Xiao Y, Qin Z. Mol Divers 24 119-130 (2020)
  54. Cai X, Liu J, Zhao F, Wang X. Genes Genomics 45 593-610 (2023)


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