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Structural basis of the autolysis of AaHIV suggests a novel target recognizing model for ADAM/reprolysin family proteins.

Zhu Z, Gao Y, Zhu Z, Yu Y, Zhang X, Zang J, Teng M, Niu L
Biochem Biophys Res Commun 386 159-64 (2009)
Cited: 14 times
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Abstract

AaHIV, a P-III-type snake venom metalloproteinase (SVMP), consists of metalloproteinase/disintegrin/cysteine-rich (MDC) domains and is homologous to a disintegrin and metalloproteinase (ADAM) family proteins. Similar to brevilysin H6 and jararhagin, AaHIV can easily autolyse to release a stable protein named acucetin, which contains disintegrin-like and cysteine-rich domains. In this study, we determined the crystal structure of AaHIV and investigated the autolysis mechanism. Based on the structure of AaHIV and the results from docking experiments, we present a new model for target recognition in which two protein molecules form a functional unit, and the DC domain of one molecule is used for target recognition while the M-domain of the other is used for target proteolysis. Our results shed new light on the mechanism of target recognition and processing in ADAM/reprolysin family proteins.

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Articles - 3hdb mentioned but not cited (4)

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Reviews citing this publication (1)

  1. Kini RM, Koh CY. Toxins (Basel) 8 E284 (2016)

Articles citing this publication (7)

  1. Guan HH, Goh KS, Davamani F, Wu PL, Huang YW, Jeyakanthan J, Wu WG, Chen CJ. J Struct Biol 169 294-303 (2010)
  2. Leonardi A, Sajevic T, Punger膷ar J, Kri啪aj I. J Proteome Res 18 2287-2309 (2019)
  3. Sajevic T, Leonardi A, Kova膷i膷 L, Lang-Balija M, Kurtovi膰 T, Punger膷ar J, Halassy B, Trampu拧-Bakija A, Kri啪aj I. Biochimie 95 1158-1170 (2013)
  4. Carbajo RJ, Sanz L, Perez A, Calvete JJ. FEBS J 282 341-360 (2015)
  5. Kong Y, Sun Q, Zhao Q, Zhang Y. Toxins (Basel) 10 E332 (2018)
  6. Zhang L, Chen C, Cao Y, Xie B, Chen X, Zeng F, Liu M. J Biochem Mol Toxicol 30 470-476 (2016)
  7. Misson Mindrebo LE, Mindrebo JT, Tran Q, Wilkinson MC, Smith JM, Verma M, Casewell NR, Lander GC, Jardine JG. Toxins (Basel) 16 361 (2024)


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